Researchers find long-lived immunity to 1918 pandemic virus

first_img “The B cells have been waiting for at least 60 years—if not 90 years—for that flu to come around again,” he said. “That’s amazing, because it’s the longest memory anyone’s ever demonstrated.” Determine if the survivors still had antibodies to the virus Aug 17 Vanderbilt University Medical Center press release The group collected blood samples from 32 pandemic survivors aged 91 to 101. The multipronged study had four components, to: The findings appeared online Aug 17 in Nature. Study collaborators hail from several institutions: Vanderbilt University, Mount Sinai School of Medicine, University of Medicine and Dentistry of New Jersey (UMDNJ), the Centers for Disease Control and Prevention (CDC), and Scripps Research Institute. Aug 19, 2008 (CIDRAP News) – A study of the blood of older people who survived the 1918 influenza pandemic reveals that antibodies to the strain have lasted a lifetime and can perhaps be engineered to protect future generations against similar strains. See if the B cells—the ones that produce the antibodies—could be cultured and produce antibodies to a 1918 virus protein Evaluate if the antibodies could protect mice infected with the 1918 influenza virus Dr Tshidi Tsibane, a study author and postdoctoral fellow in Mount Sinai School of Medicine’s microbiology department, said in a press release from Mount Sinai that though there is no need for a new treatment for 1918 influenza virus infections, the results are still useful. The investigators generated B lymphoblastic cell lines from the peripheral blood mononuclear cells of eight subjects. Transformed cells from the blood of 7 of the 8 donors yielded secreting antibodies that bound the 1918 hemagglutinin. From the B cells of three donors, the research group generated five monoclonal antibodies that not only strongly neutralized the 1918 virus, but also cross-reacted with proteins related to the 1930 swine flu virus. However, the antibodies did not react against more contemporary influenza strains. Author James E. Crowe, Jr, MD, professor of pediatrics and director of the Vanderbilt Program in Vaccine Sciences, said in a press release from Vanderbilt that the researchers were surprised by the findings.center_img Attempt fusing cells having the highest levels of activity with myeloma cells to create a hybrid cell line that secretes monoclonal antibodies The people recruited for the study were 2 to 12 years old in 1918 and many recalled sick family members in their households, which suggests they were directly exposed to the virus, the authors report. The group found that 100% of the subjects had serum-neutralizing activity against the 1918 virus and 94% showed serologic reactivity to the 1918 hemagglutinin. Xiaocong Y, Tsibane T, McGraw P, et al. Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors. Nature 2008 (published online Aug 17) [Abstract] Aug 17 Mount Sinai School of Medicine press release Inspiration for the study came from an unlikely source, an episode of an old medical television show that portrayed a town protecting itself from the 1918 virus outbreak by using blood from an elderly survivor, the Associated Press (AP) reported yesterday. The storyline prompted Eric Altschuler, MD, a professor of physical medicine and rehabilitation at UMDND to ask the National Institutes of Health (NIH) for a grant to test people over age 90 for the 1918 flu antibodies, according to the AP report. The NIH funded much of the study and enlisted the expertise of other experts. Anthony Fauci, MD, director of the National Institute of Allergy and Infectious Diseases, said recent studies have projected that immunity lasts several decades; the current study provides proof, the AP reported. “This is the mother of all immunological memory here,” he told the AP. The authors point out that it is difficult to be certain that the monoclonal antibodies they isolated were first stimulated during the 1918 influenza pandemic. However, they write that the subjects’ clinical histories and the high affinity of the monoclonal antibodies for the 1918 strain “strongly suggest that recent exposures do not account for this immunity.” They add that exposure to similar viruses circulating during first part of the 20th century probably bolstered the subjects’ B cell function. “These findings could serve as potential therapy for another 1918-like virus,” said Dr Tsibane in the statement. In the final arm of the study, the researchers infected mice with the reconstructed 1918 virus and the next day tested the five monoclonal antibodies at various doses to see if the therapy protected the animals. The mice receiving the lowest dose of the 1918 monoclonal antibody died, as did the ones receiving the control antibody. All given the highest antibody doses survived. See also:last_img read more

Fighting spirit wins for England

first_img Fighting spirit won through to give England a narrow 4-3 victory over France in an U21 women’s match at St Cloud today. Lancashire’s Sophie Lamb – playing in the last game – secured the victory with an impressive comeback. The 17-year-old had been one down with three to play but snatched her point with a birdie on the last hole. Inci Mehmet and Alice Hewson led the way with wins at the top of the order, but then the French edged ahead by winning the next three games. Gemma Clews stopped their run when she won her match on the last green and shortly afterwards Lamb (image © Leaderboard Photography) sealed the result.   The match was a warm-up for the French U21 ladies’ championship which starts at St Cloud tomorrow and the players earned the praise of England women’s coach Steve Robinson. “I was very pleased with the way we holed out and the fighting spirit that each of the players showed, taking matches down to the last couple of holes,” he said. “This is a great result against a strong country – France are the reigning European champions – but the players are putting it behind them to focus on the start of the tournament tomorrow. This is a great springboard for the rest of the week.” Cornwall’s Sammie Giles had to withdraw from the match, having been ruled out of the championship because of injury. Her place was taken by Hampshire’s Emma Allen. Results Inci Mehmet (Royal Mid-Surrey) beat Marion Veysseyre 3/2 Alice Hewson (Berkhamsted) beat Anyssia Herbaut  2/1 India Clyburn (Woodhall Spa) lost to Eva Gilly 2/1 Emma Allen (Meon Valley) lost to Lauralie Migneaux 2 down Bethan Popel (Long Ashton) lost to Elisabeth Codet 3/2 Gemma Clews (Delamere Forest) beat Chloe Salort 1 up Sophie Lamb (Clitheroe) beat Mathilde Claisee & Pauline Roussin Bouchard (playing foursomes) 1 up 1 Apr 2015 Fighting spirit wins for England last_img read more

How to design a great golfing experience

first_imgThe club has worked with Jonathan Barker from Golf Business International to improve the flow around the facility and give members and visitors a better experience.Previously, arriving golfers were channelled around the side of the clubhouse and onto the course.Now the main clubhouse doors have been opened up to all traffic, including bags and trolleys, taking golfers into a courtyard at the centre of the clubhouse.There’s easy access to the pro shop and readily available ‘grab & go’ catering from a developing café-style area. This maximises the benefit of the clubhouse also being the halfway house.Everyone arriving is made aware of news, offers and events as they come through Reception and this has proved a great aid to communication.The club is about to launch a 9-hole FootGolf course on what was surplus land, used just once a year for overflow parking. Now it could provide additional income for the club.General Manager Gordon MacLeod commented: “Our engagement with Jonathan and Golf Business International has caused us to look at what we currently have from a perspective that slight tinkering could make a significant difference.”The club is also working with Jonathan on longer-term proposals.Image shows an illustration from the guide. 17 May 2018 How to design a great golfing experience A new guide which shows how good design can make golf clubs more customer friendly has been produced by England Golf.The Customer Focused Facility Guidance aims to help clubs and golf centres to match the design, character and appearance of their course and clubhouse to the needs of their members and visitors.Abbie Lench, England Golf Head of Club Support commented: “This is so important. The look and feel of your club will directly affect customers and influence their decision to return – or not.“The first step to designing a successful business is to understand what customers want. This will also help clubs tap into new markets to attract more players and members, become a hub for the local community and create better products and services.”The guide has been produced with the support of Sport England and input from Golf Business International (GBI), a consultancy which is one of England Golf’s Preferred Partners and offers a wide range of knowledge and expertise across all areas of golf business including course architecture and facility management. A wide range of golf facilities have also contributed information.It looks at ways to improve the playing and social environment both within existing facilities and as part of any new build project.It steers clubs through the process of reviewing their facilities – both on and off the course – and comparing them with the local competition, identifying areas for improvement, looking at all the options and drawing up a statement of requirements.The guide considers everything from signage on the site to the features of the clubhouse, including its appeal from the road or pathway, the welcome of the reception area and how this links with other areas such as the bar, the changing rooms and the professionals’ shop. Transport links and car parking are among the other areas for consideration.It suggests possible solutions which range from simple steps to remove barriers or improve navigation around the site, to completely new facilities to attract a wider customer base, such as a coffee shop.On the course it looks at ways to increase customer appeal and capacity such as variable tees positions for all abilities, programing to offer Speedgolf, Footgolf or play over short loops of holes, and the customer flow, both around the course and from the clubhouse to the course and back.Howard Swan of Golf Business International commented: “I am delighted as Chairman of Golf Business International to have been able to contribute to and support this excellent publication.“It will be greatly welcomed in the market place and gives essential help and guidance to clubs as to the way forward for the game’s essential, changing future. Our 30 GBI consultants are on hand to support England Golf through our partnership programme in helping to put the initiatives which the facilities guide explains so very well”.Sport England’s Director of Property Charles Johnston added: “Sport England has supported England Golf to put customer’s needs at the heart of the new guidance, taking into account people’s habits and their preferences, their wider lives, needs and wishes.“The guidance will help golf clubs design facilities with the best chance of retaining players and attracting new ones.”The guide complements England Golf’s package on Understanding Your Market. This helps clubs to understand their customers and to attract and retain members by providing the golfing experience they want. It also offers the use of mapping tools to show where potential customers can be found.Clubs should contact their England Golf regional manager or club support officer for more information or a copy of the guidance. Click here for contact detailsCase study: St Ives Golf Club, Huntingdoncenter_img Tags: Customer, Facility Guidancelast_img read more